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Am. J. Trop. Med. Hyg., 47(4), 1992, pp. 512-520
Copyright © 1992 by The American Society of Tropical Medicine and Hygiene

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Albendazole in the Treatment of Onchocerciasis: Double-Blind Clinical Trial in Venezuela

Barnett L. Cline, Jesus Luque Hernandez, Frances J. Mather, Richard Bartholomew, Sonia Nunez De Maza, Sara Rodulfo, Charles A. Welborn, Mark L. Eberhard AND Jacinto Convit
Departments of Tropical Medicine, and Biostatistics and Epidemiology, School of Public Health and Tropical Medicine, Tulane University Medical Center, New Orleans, Louisiana; Ministry of Health, Caracas, Venezuela; Central University Hospital Dr. Manuel Nunez Tovar, Maturin, Monagas State, Venezuela; Instituto de Biomedicina, Caracas, Venezuela

A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection. Forty-nine patients (26 treated and 23 controls) received a 10-day course of albendazole (400 mg/day) or a placebo. Consistent with the excellent tolerance observed, albendazole did not kill microfilariae. However, analysis of changes in microfilarial densities (mf/mg of skin) over one year showed that albendazole was active against O. volvulus, presumably by interfering with embryogenesis. The nature, degree, and duration of this effect remain to be determined.






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Copyright © 1992 by the American Society of Tropical Medicine and Hygiene.