HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Armstrong, A. L. Articles by Beck, D. S. Search for Related Content PubMed PubMed Citation Articles by Armstrong, A. L. Articles by Beck, D. S.

Carditis in Lyme Disease Susceptible and Resistant Strains of Laboratory Mice Infected with Borrelia Burgdorferi

The clinical and pathologic evolution of cardiac Lyme disease was evaluated in four-week-old susceptible C3H/He (C3H) and resistant C57Bl/6 (B6) mice on days 3, 6, 10, 15, 30, 60, and 90 after intradermal inoculation with Borrelia burgdorferi strain N40. Culture, DNA polymerase chain reaction, in situ nucleic acid hybridization, immunoperoxidase histochemical analysis, and silver stain were used to detect spirochetes. Spirochetes were first detected by culture on day 6 in two of four C3H mice. The hearts of all mice of both genotypes were culture positive by day 10 and infection persisted through day 90. The spirochetes had a predilection for connective tissue in the heart base, especially around the aorta, epicardium of the upper ventricles and atria, myocardial interstitium, and endocardium. Carditis was first detectable on day 10, reaching a maximum severity on day 15, then resolved, except for persistence of periaortic lymphoplasmacytic infiltrates through day 90 in C3H mice and through day 60 in B6 mice. The C3H mice developed more severe disease than the B6 mice, and this was associated with the earlier appearance, greater numbers, and later clearance of spirochetes in C3H mice. Electrocardiographs of infected and control mice revealed bradycardia and tachycardia in many C3H mice, but in very few B6 mice. Serum creatinine phosphokinase levels did not become elevated at any interval.

This article has been cited by other articles:

				C. R. Brown, A. Y.-C. Lai, S. T. Callen, V. A. Blaho, J. M. Hughes, and W. J. Mitchell Adenoviral Delivery of Interleukin-10 Fails To Attenuate Experimental Lyme Disease Infect. Immun., December 1, 2008; 76(12): 5500 - 5507. [Abstract] [Full Text] [PDF]

				G. Wang, M. M. Petzke, R. Iyer, H. Wu, and I. Schwartz Pattern of Proinflammatory Cytokine Induction in RAW264.7 Mouse Macrophages Is Identical for Virulent and Attenuated Borrelia burgdorferi J. Immunol., June 15, 2008; 180(12): 8306 - 8315. [Abstract] [Full Text] [PDF]

				E. Hodzic, S. Feng, K. Holden, K. J. Freet, and S. W. Barthold Persistence of Borrelia burgdorferi following Antibiotic Treatment in Mice Antimicrob. Agents Chemother., May 1, 2008; 52(5): 1728 - 1736. [Abstract] [Full Text] [PDF]

				R. R. Montgomery, C. J. Booth, X. Wang, V. A. Blaho, S. E. Malawista, and C. R. Brown Recruitment of Macrophages and Polymorphonuclear Leukocytes in Lyme Carditis Infect. Immun., February 1, 2007; 75(2): 613 - 620. [Abstract] [Full Text] [PDF]

				S. W. Barthold, E. Hodzic, S. Tunev, and S. Feng Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect. Immun., August 1, 2006; 74(8): 4817 - 4825. [Abstract] [Full Text] [PDF]

				N. Parveen, K. A. Cornell, J. L. Bono, C. Chamberland, P. Rosa, and J. M. Leong Bgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice. Infect. Immun., May 1, 2006; 74(5): 3016 - 3020. [Abstract] [Full Text] [PDF]