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Experimental Infection of the Gibbon (Hylobates Lar) with Dirofilaria Immitis^*

Four gibbons were inoculated subcutaneously with larvae of Dirofilaria immitis and studied for periods of time up to 14 months. Approximately 2 months following inoculation, skin test reactions converted to positive, eosinophil counts rose, and serological tests were positive for Dirofilaria-reactive antibody. Generally, these laboratory manifestations of infection persisted for the remainder of the study, but microfilaremia was never detected. Both live and dead heartworms were found in the heart and lungs of the infected animals. The pulmonary lesions associated with the infection closely resembled those reported in dogs.

Accepted for publication April 15, 1972.

^* The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences-National Research Council.