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BCG Vaccination

Studies by the WHO Tuberculosis Research Office, Copenhagen, Monograph Series No. 12. By Lydia B. Edwards, Chief of Field Studies, Carroll E. Palmer, Director, and Knut Magnus, Assistant Statistician. 307 pp. Geneva, World Health Organization, Palais des Nations. 1953. Price: 15/-; $3.00; Sw. fr. 12.-

This three-hundred page monograph provides the first coordinated account of an elaborate investigation of BCG vaccination organized by the Tuberculosis Research Office of the World Health Organization and conducted in cooperation with the International Tuberculosis Campaign and Statens Seruminstitut of Copenhagen. It sets forth the results of three years of intensive study of a number of crucial problems which must be solved before a satisfactory estimate of the value of BCG vaccination is possible. The volume deals largely with the development of tuberculin allergy after BCG vaccination, a phenomenon in which the character of the vaccine and the manner of its administration are highly important. Response to tuberculin is recognized by the authors as the only guide presently available on the effectiveness of the vaccinating procedure. Chapters are included on the effects of light, heat and storage on the potency of the vaccine as measured by development of allergy, and on the relative roles of dead and live bacilli in various preparations of the vaccine in eliciting allergy.