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Paragonimiasis: Failure of Nilodin in Therapy and Report of One Case with Urinary Tract Involvement

Seven patients with pulmonary paragonimiasis were treated with Nilodin for a period of 6 days, receiving a total dose of 75 mg. per kg. body weight. Four other patients were studied as untreated controls. All were followed before and after therapy by egg counts made on 24-hour sputum specimens using a sodium hydroxide digestion technique. Based on these counts, as well as on the clinical response, Nilodin had no effect on any of the patients to whom the drug was administered. A case of Paragonimus infection involving not only the lungs but the urinary tract as well was studied. The patient passed eggs in the urine continuously, with pus cells generally adherent to the egg shells. An average of 5,966 eggs was passed in the urine per day. Treatment with a combination of emetine, sulfadiazine and Nilodin caused the disappearance of eggs from the urine and sputum based on examinations conducted during the 8-week period which followed the initiation of therapy. It is believed the Nilodin did not influence the disappearance of eggs in this case, but that this was probably due to the combined action of emetine and sulfadiazine.

¹ Member, Joint Dysentery Unit, Commission on Enteric Infections, Armed Forces Epidemiological Board and Federal Security Agency, Public Health Service, National Institutes of Health, National Microbiological Institute, Laboratory of Tropical Diseases, Bethesda, Md.

² 1st Lt., M.C.

^3,4 Pfc., 64th Field Hospital, APO 59, c/o PM, San Francisco, California.

⁵ The authors wish to thank Lt. Col. Robert Bell, Commanding Officer, 64th Field Hospital, and Captain Philip Deaver, Chief of Medicine, for the cooperation extended to us during this study.