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Filariasis in American Samoa

III. Studies on Chemotherapy Against the Nonperiodic Form of Wuchereria Bancrofti¹

Diethylcarbamazine is rapidly microfilaricidal but there has been no demonstration that the adult worms are killed. Its possible place as an adjuvant public health measure in the control of filariasis is yet to be demonstrated. Thiacetarsamide is very slowly microfilaricidal but the results are more permanent and that, together with collateral laboratory evidence, suggests that the adult worms are killed. This drug must however, be, given intravenously, apparently daily for not less than 15 days, and thus has limited value as a community-wide public health measure.

¹ Later phases of this work were supported in part by a contract between the Office of Naval Research and The Johns Hopkins University. These studies were made possible by the cooperation of the Fita Fita Guards who enthusiastically volunteered as pilot cases. We wish to thank Captain W. P. Stephens (M.C. U.S.N.) for making available the personnel and facilities of the U. S. Naval Dispensary in Samoa. M. H. Powell, H.M.C., U.S.N. and H. H. Marrer, H.M.C., U.S.N. rendered technical assistance. The opinions and statements herein are those of the authors and not necessarily those of the Navy Department.