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Am. J. Trop. Med. Hyg., 2(3), 1953, pp. 420-428
Copyright © 1953 by The American Society of Tropical Medicine and Hygiene

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The Clinical Manifestations and Laboratory Diagnosis of Toxoplasmosis1

Harry A. Feldman2
Department of Medicine, State University of New York, Medical College at Syracuse, New York and the Kilian Research Laboratory, Wieting-Johnson Hospital for Rheumatic Diseases

Since the topic which I have been assigned is quite broad and the allotted time definitely limited, it will not be possible for me to refer as completely as I should like to the contributions of others nor to acknowledge the sources of the many specimens which we have studied. My discussion will be divided into three parts: (a) the laboratory procedures which are considered to be most helpful for making the diagnosis of toxoplasmosis; (b) the clinical manifestations of infection with Toxoplasma in humans and animals; (c) epidemiological information obtained from the large scale application of some of the serological methods.

A. The Laboratory Diagnosis of Toxoplasmosis. The most precise way in which to gather laboratory support for the diagnosis of toxoplasmosis obviously is to isolate the parasite from the ill human or animal. On this score I would strongly recommend that laboratory-reared mice be used for such attempts, since we have never encountered spontaneous toxoplasmosis in such animals.


1 All studies which have been performed in our laboratory have been made possible principally by grants-in-aid from the National Institutes of Health, United States Public Health Service, Bethesda, Maryland. Partial support has been received from the Hendricks Research Fund and the Masonic Foundation for Medical Research and Human Welfare.


2 The author is indebted to Louise T. Miller for aid in the conduct of some of the studies included in this presentation.




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Copyright © 1953 by the American Society of Tropical Medicine and Hygiene.