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The Effect of a Cyanine Dye on Infections with Hookworm and Trichuris in Man¹

The administration of compound #715 to patients infected with hookworm caused expulsion of some of the adult worms. As the doses and frequency of administration increased, the number of worms expelled also increased, but it was never as effective nor as well tolerated as tetrachlorethylene. Adult Trichuris trichiura also were passed during administration of #715.

Frequent complaints during drug administration were nausea, vomiting, and epigastric pain. These reactions, however, did not warrant discontinuation of treatment.

¹ We are grateful to Parke, Davis and Company for an adequate supply of the cyanine dye (#715) in encapsulated form.