HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Nakamura, M. Articles by Anderson, H. H. Search for Related Content PubMed PubMed Citation Articles by Nakamura, M. Articles by Anderson, H. H.

Drug Effects on the Metabolism of Endamoeba Histolytica; in Vitro and in Vivo Tests of Synergism

1. An in vitro method is described for measuring the anaerobic metabolism of E. histolytica in terms of acid and CO₂ formation, utilizing manometric technics.

2. The effects of several agents on the metabolic activity of amebas have been studied. Synergism was observed when drug combinations were tested in vitro, notably with fumagillin and terramycin and with fumagillin and thiocarbarsone (C.C. 914).

3. Four of five naturally infected macaques were cleared over a 12 week period when the smallest effective oral dose of fumagillin and terramycin (each 12.5 mgm./Kg.) were given together daily over ten days.

¹ With the technical assistance of Mrs. Betty Mythen and Miss Dorothy Swanman. Consultation with Drs. Jon L. Karlsson and Blair M. Bennett is also acknowledged with gratitude, in certain technical aspects of this study.

² Supported, in part, by the National Institutes of Health, United States Public Health Service, Bethesda, Md.