AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 19(6), 1970, pp. 996-1000
Copyright © 1970 by The American Society of Tropical Medicine and Hygiene

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Comparison of Formation of Granulomata around Eggs of Schistosoma Mansoni in the Mouse, Guinea Pig, Rat, and Hamster*

C. Amechi Akpom, M. F. Abdel-Wahab{dagger} AND Kenneth S. Warren{ddagger}
Departments of Preventive Medicine and Medicine, Case Western Reserve University School of Medicine, and University Hospitals, Cleveland, Ohio 44106

A model of the immunopathology of the granulomatous response to Schistosoma mansoni eggs (a form of delayed hypersensitivity) has been established in the mouse. For certain types of investigation of granuloma formation, however, other species of laboratory animals may be preferable. Thus eggs of S. mansoni were injected into the microvasculature of the lungs of rats, guinea pigs, and hamsters as well as mice. The response of the rodents was temporally and qualitatively similar, although the lesions differed in size.

Accepted for publication May 5, 1970.


* This investigation was supported in part by grants from The Rockefeller Foundation, USPHS grant No. FR-05410-08, and the US-Japan Cooperative Medical Science Program administered by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (grant No. AI31814-03).


{dagger} On leave from the Department of Clinical Tropical Medicine, Cairo University, Cairo, United Arab Republic.


{ddagger} Holder of USPHS Career Development Award AI 08163-03.






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Copyright © 1970 by the American Society of Tropical Medicine and Hygiene.