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Am. J. Trop. Med. Hyg., 19(6), 1970, pp. 932-939
Copyright © 1970 by The American Society of Tropical Medicine and Hygiene

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Immunosuppression in Experimental Acute and Subacute Chagasic Myocarditis*

Raj Kumar{dagger}, Irwin K. Kline{ddagger} AND Walter H. Abelmann§
Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital 02118, and the Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts 02115

One hundred twenty weanling and 168 adult, male C3H mice were studied to determine the possible role of immune processes in the pathogenesis of Chagasic cardiomyopathy. Experimental myocarditis was produced with a Colombian strain of Trypanosoma cruzi. Cyclophosphamide, 40 mg per kg, was used for immunosuppression, and it was administered in the early, the subacute, and the late subacute phases of the disease. Immunosuppression uniformly increased mortality, parasitemia, and the severity of myocarditis. Involvement and dilatation of the right ventricle dominated, without gross dilatation or hypertrophy of the left ventricle. The immune responses in Chagas' disease are beneficial to the host. Immunosuppressive therapy may be hazardous in patients with Chagas' disease.

Accepted for publication March 19, 1970.


* This work was supported in part by Grants HE 5244 and HE 10539 from the National Heart Institute, National Institutes of Health, U.S. Public Health Service. Please address requests for reprints to Dr. Abelmann, Thorndike Memorial Laboratory, Boston City Hospital, 818 Harrison Avenue, Boston, Massachusetts 02118.


{dagger} Intructor in Medicine, Harvard Medical School, and Research Associate, Thorndike Memorial Laboratory, Boston City Hospital.


{ddagger} Formerly Clinical Associate in Pathology, Harvard Medical School. Presently Director of Pathology, The Lankenau Hospital, Philadelphia, Pennsylvania.


§ Associate Professor of Medicine, Harvard Medical School. Physician, Thorndike Memorial Laboratory, Boston City Hospital.






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