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Induction of an Interferon-Like Inhibitor by Trypanosoma Cruzi Infection in Mice^*

Michael W. Rytel AND Philip D. Marsden

Infection of mice with Trypanosoma cruzi of the Perú strain was associated with the appearance in the circulation of a viral inhibitor that fulfilled most requirements for classification as an interferon. The inhibitor reached its highest titer several days after infection and persisted, although in diminishing amounts, in the circulation until the termination of the experiment. The peak response preceded by several days the marked parasitic multiplication as evidenced by the number of nests of amastigotes in the heart.

Accepted for publication April 9, 1970.

^* Supported in part by training grant AI-00320 and research grant AI-07299 from the U. S. Public Health Service, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

Please address requests for reprints to Dr. M. W. Rytel, Marquette School of Medicine, Milwaukee County General Hospital, Milwaukee, Wisconsin 53226.