HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Strickland, G. T. Articles by Kostinas, J. E. Search for Related Content PubMed PubMed Citation Articles by Strickland, G. T. Articles by Kostinas, J. E.

Folic Acid Deficiency Complicating Malaria^*

G. Thomas Strickland AND John E. Kostinas

American marines in Vietnam were shown to have megaloblastic changes in bone marrow aspirates and an inappropriate reticulocyte response to anemia associated with malaria. Convalescence was prolonged because of delayed correction of anemia. These patients had normal serum vitamin B-12 levels, reduced serum folic acid, and a reticulocyte response to "physiological" doses of folic or folinic acid. Nonmalaria patients had similar abnormalities. but with a reduced incidence. The cause of the folic acid deficiency is most likely multiple: 1) inadequate dietary folate, 2) reduced absorption of folic acid, 3) increased utilization of folic acid owing to the hemolysis and fever of malaria, and 4) drug inhibition by the antimalaria chemotherapy.

Accepted for publication June 9, 1970.

^* This work was published in abstract form in 1970 in Clinical Research, 18: 418, and was supported by the Bureau of Medicine and Surgery, Department of the Navy, Work Unit M4305.06-3005A. The opinions or assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large. Please address requests for reprints to Publications Editor, NAMRU-2, Box 14, APO San Francisco 96263.

Department of Clinical Investigation, U.S. Naval Medical Research Unit 2, Taipei, Taiwan, Republic of China. Present address: London School of Hygiene and Tropical Medicine, Keppel and Gower Street, London, WC1.

Present address: U.S. Naval Hospital, Portsmouth, Virginia 23708.

This article has been cited by other articles:

				R. Stolzenberg Possible Folate Deficiency With Postsurgical Infection Nutr Clin Pract, December 1, 1994; 9(6): 247 - 250. [Abstract] [PDF]