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Am. J. Trop. Med. Hyg., 19(6), 1970, pp. 905-909
Copyright © 1970 by The American Society of Tropical Medicine and Hygiene

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An in Vitro System for Screening Potential Antimalarial Drugs*

Craig J. Canfield, Leslie B. Altstatt AND Van B. Elliot
Division of Medicine, Walter Reed Army Institute of Research, Washington, D. C. 20012

Evaluation of large numbers of potential antimalarial agents requires systems that are simple, reliable, and accurate. We used one such system that employed multiple, dilute, in vitro cultures of Plasmodium knowlesi to assess effectiveness of drugs. Assessment was made by observation of changes in morphologic maturation of the parasites, incorporation of 14C-methionine into protein, and lactic acid production. Reliability was demonstrated by reproducible dose-response relations of known antimalarial drugs.

Accepted for publication July 10, 1970.


* Presented before the 17th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Atlanta, Georgia, 30 October 1968. This paper is contribution number 729 from the Army Malaria Research Program.






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Copyright © 1970 by the American Society of Tropical Medicine and Hygiene.