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Antivenin for the Treatment of Local Tissue Damage Due to Envenomation by Southeast Asian Snakes

Ineffectiveness in the Prevention of Local Tissue Damage in Mice after Envenomation^*

Antivenins currently used in Southeast Asia to treat snake-bite were administered to mice to determine their effectiveness in the prevention of local tissue damage after envenomation. Antivenins were more effective when injected immediately after venom injection or mixed with venom before injection. When the antivenin was given 10 and 30 minutes later, its effectiveness was reduced accordingly. Intravenous injection of antivenin was more effective in preventing death than intramuscular injection.

Accepted for publication February 11, 1970.

^* This work was supported by U. S. Public Health Service grant No. 5R01 FD-00014, 5R01 GM-15591-03, and a Career Development Award 5K04 GM-41786-02 from National Institutes of General Medical Sciences, NIH, to A. T. Tu.