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Prevalence of Serum-Hepatitis-Related Antigen (SH) in Different Geographic Regions^*

An Ouchterlony test that appears to identify a proportion of carriers of serum hepatitis has been utilized to estimate the prevalence of this state in some tropical populations from Africa, Asia, and South America. The serum hepatitis-related antigen (Australia/SH/"Hepatitis antigen") has been found to be 10 to 100 times more prevalent in these tropical populations than in volunteer blood donors in New York City. These findings confirm previous results obtained by testing for the Australia antigen. Analysis of the data revealed no significant difference in the prevalence of hepatitis-related antigen between males and females and, with the exception of one population, did not suggest a decline in frequency of serum containing antigen with increasing age. The findings are compatible with the previously suggested hypothesis that arthropods may play a role in transmission of serum-hepatitis virus in the Tropics.

Accepted for publication February 3, 1970.

^* These studies were supported by Grant No. HE 09011 of the National Heart Institute, NIH, and a grant-in-aid from the Irwin Strasburger Memorial Medical Foundation. A. M. Prince is the recipient of a Career Scientist Award of the Health Research Council of the City of New York under Contract No. I-533.