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Neutralization of the Vascular Permeability Factor of Vibrio Cholerae in Man

Albert R. Martin^*, Thomas M. Vernon AND Wiley H. Mosley

Epidemiology Section, Pakistan-SEATO Cholera Research Laboratory, Dacca, East Pakistan

The vascular permeability factor (PF) is one of the toxins derived from Vibrio cholerae that may play a role in the production of cholera diarrhea. A prospective study was performed among persons in an area endemic for cholera to determine if the ability to neutralize PF could be correlated with protection against cholera. Patients with cholera and their families were skin-tested with PF immediately after admission of the first patient to the hospital, and family members were followed for 10 days for bacteriologic evidence of infection and for symptoms of cholera. Results showed no evidence that ability to neutralize vascular PF could be associated with protection against V. cholerae infection or modification of the symptoms of the illness. In contrast, the vibriocidal antibody titer during the acute phase of infection did correlate well with resistance to cholera.

^* Present address: Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114.

Present address: U.S.A.I.D. Malaria Eradication Program, Kathmandu, Nepal.

The Pakistan-SEATO Cholera Research Laboratory is a part of the SEATO Cholera Research Program and is supported by the U. S. Agency for International Development, Department of State; the National Institutes of Health and the National Communicable Disease Center of the Department of Health, Education, and Welfare; and by the Governments of Pakistan, United Kingdom, and other SEATO nations. The NIH Cholera Advisory Committee coordinates the research program. These studies were supported in part by Research Agreement No. 196802 between the National Institutes of Health, Bethesda, Maryland, U.S.A., and the Pakistan-SEATO Cholera Research Laboratory, Dacca, East Pakistan.