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Am. J. Trop. Med. Hyg., 16(6), 1967, pp. 693-698
Copyright © 1967 by The American Society of Tropical Medicine and Hygiene

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Effects of Pyrimethamine, Chlorguanide, and Primaquine against Exoerythrocytic Forms of a Strain of Chloroquine-Resistant Plasmodium Falciparum from Thailand*

Robin D. Powell AND George J. Brewer{dagger}
Army Medical Research Unit of the Department of Medicine, Division of the Biological Sciences, The University of Chicago, Chicago, Illinois

Studies to assess the potential causal prophylactic value of chlorguanide, pyrimethamine, and primaquine against a strain of chloroquine-resistant P. falciparum, the Thailand (JHK) strain, indicated that daily administration of chlorguanide, weekly administration of pyrimethamine, or weekly administration of primaquine may prove far from uniformly effective.


* These studies, made possible through the cooperation of the inmates and the administrative staff of the Illinois State Penitentiary, Stateville Branch, Joliet, Illinois, were supported by the Medical Research and Development Command, Office of the Surgeon General, Department of the Army, under Contracts DA-49-007-MD-566 and DA-49-007-MD-2413 with The University of Chicago. This paper is contribution No. 197 from the Army Research Program on Malaria.


{dagger} Present address: Departments of Medicine (Simpson Memorial Institute) and Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan.




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D. R. HILL, J. K. BAIRD, M. E. PARISE, L. S. LEWIS, E. T. RYAN, and A. J. MAGILL
PRIMAQUINE: REPORT FROM CDC EXPERT MEETING ON MALARIA CHEMOPROPHYLAXIS I.
Am J Trop Med Hyg, September 1, 2006; 75(3): 402 - 415.
[Abstract] [Full Text] [PDF]


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Copyright © 1967 by the American Society of Tropical Medicine and Hygiene.