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Chemotherapy of Sporozoite- and Blood-Induced Plasmodium Berghei Infections with Selected Antimalarial Agents^*

On the basis of these preliminary observations, it appears that, provided suitable temperature-controlled insectaries are available, the A. stephensi-A/J mouse P. berghei cycle is a useful model for the evaluation of various applications of antimalarial agents including causal prophylaxis, suppressive, and curative therapy.

The short prepatent period must be considered together with the duration of persistence of the drug in blood or tissues in determining causal prophylaxis. An adequate dosage of sporozoites, which results in ready detection of exoerythrocytic stages in control and pretreated animals, is essential.

The response of sporozoite-induced infection with P. berghei to antimalarial drugs resembles in several ways that seen both in P. vivax and P. falciparum.

^* This work, contribution No. 185 from the Army Research Program on Malaria, was carried out under the sponsorship of the Commission on Malaria, Armed Forces Epidemiological Board, and supported by the U.S. Office of The Surgeon General, Department of the Army.