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Mosquito-Induced Infection with Equine Encephalomyelitis Virus in Dogs^*,,

W. S. Bivin, C. Barry, A. L. Hogge, Jr. AND E. C. Corristan

Dogs infected with Venezuelan equine encephalomyelitis virus via the bite of infected Aedes triseriatus responded with fever and hemagglutination-inhibiting antibodies. Even though high temperatures were elicited in 14 of the animals, in only seven did viremia develop above 10^2.5 mouse intraperitoneal median lethal dose₅₀ per ml. Sufficient quantities of mosquitoes were infected from the dogs to permit passage of the virus on to guinea pigs. There were no other clinical signs of illness observed in the animals.

^* In conducting the research reported herein, the investigators adhered to "Guide for Laboratory Animal Facilities and Care," established by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences, National Research Council.

Please address requests for reprints to: U. S. Army Medical Unit, Fort Detrick, Frederick, Maryland 21701.

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Present address: Civil Defense Material Division, DSAH-OTR, Defense Supply Agency, Cameron Station, Alexandria, Virginia 22314.