HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kokernot, R. H. Articles by Worth, C. B. Search for Related Content PubMed PubMed Citation Articles by Kokernot, R. H. Articles by Worth, C. B.

Ndumu Virus, a Hitherto Unknown Agent, Isolated from Culicine Mosquitoes Collected in Northern Natal, Union of South Africa^*

R. H. Kokernot, B. M. McIntosh AND C. Brooke Worth

A virus strain (AR 2204) was isolated from a pool of 19 Mansonia (Mansonioides) uniformis (Theobald); another virus strain (AR 2211) was isolated from a pool of 278 Aedes (Neomelaniconion) circumluteolus (Theobald).

Serological studies utilizing CF and NT techniques have shown the two virus strains to be immunologically indistinguishable. Similar studies including also the HI technique indicate that the virus is not related to a wide spectrum of other arthropod-borne viruses. The agent has been named Ndumu virus after the locality where the mosquitoes were collected.

Ndumu virus is sensitive to the action of sodium desoxycholate. A vervet monkey was inoculated with Ndumu virus and the agent was detected in the serum on the 8th and 10th postinoculation days. Protection test surveys indicate that Ndumu virus has been active among human beings residing in widely scattered areas in southern Africa.

^* The studies and observations on which this paper is based were financed jointly by the South African Institute for Medical Research, the Poliomyelitis Research Foundation, the South African Council for Scientific and Industrial Research and The Rockefeller Foundation.

Present address: The Rockefeller Foundation, 111 West 50th Street, New York 20, New York.